The Creative Destruction Lab (CDL) is a seed-stage program for massively scalable, science-based companies. The nine-month program employs an objectives-based mentoring process with the goal of maximizing equity-value creation. The CDL is particularly suited to early stage companies with links to university research labs. Companies that graduated from the Lab’s first five cohorts between 2012 and 2017 have generated more than $2.5 billion (CAD) in aggregate equity value. CDL graduates include Atomwise (San Francisco), Deep Genomics (Toronto), Thalmic Labs (Waterloo), Nymi (Toronto), Automat (Montreal), BenchSci (Toronto), Kyndi (Palo Alto), Kepler (Toronto), and Heuritech (Paris).